Publications

Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers.

2025

Fischer DL, Grinberg LT, Ahrendsen JT, Beach TG, Bieniek KF, Castellani RJ, Chkheidze R, Cobos I, Cohen M, Crary JF, Dickson DW, Dugger BN, Dunlop SR, Farrell K, Ghetti B, Haeri M, Harrison W, Head E, Hiniker A, Huang EJ, Huttner A, Jamshidi P, Kapasi A, Keene CD, Kofler J, Latimer CS, McKee AC, Mente K, Miller MB, Montine TJ, Morris M, Murray ME, Nelson PT, Newell KL, Perrin RJ, Ramani B, Reichard RR, Roy S, Schlachetzki JCM, Seeley WW, Serrano GE, Spina S, Teich AF, Wang SJ, Wisniewski T, Lee EB

Burden of psychiatric disease inversely correlates with Alzheimer's age at onset.

2025

Eijansantos E, Allen IE, de Leon J, Grasso S, Rogers N, Bogley R, Paramo A, Ehrenberg AJ, Montembeault M, Sturm V, Spina S, Grinberg LT, Seeley WW, Rankin KP, Kramer JH, Rosen HJ, Rabinovici GD, Gorno-Tempini ML, Miller BL, Perry DC, Miller ZA

A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain.

2025

Belchikov N, Hu W, Fan L, Joglekar A, He Y, Foord C, Jarroux J, Hsu J, Pollard S, Amin S, Prjibelski AD, Gong S, Zhang S, Giannelli R, Seelaar H, Tomescu AI, Ross ME, Li AN, Grinberg LT, Spina S, Miller BL, Cooper-Knock J, Snyder MP, Seeley WW, Rao-Ruiz P, Spijker S, Smit AB, Clelland CD, Gan L, Tilgner HU

Co-pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms.

2025

Gibson LL, Grinberg LT, Paes VR, Mueller C, Leite REP, Nunes PV, Justo AFO, Pasqualucci CA, Ferriolli E, Aarsland D, Suemoto CK

Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype.

2025

Miller ZA, Ossenkoppele R, Graff-Radford NR, Allen IE, Shwe W, Rosenberg L, Olguin DJ, Erkkinen MG, Butler PM, Spina S, Yokoyama JS, Desikan RS, Scheltens P, van der Flier W, Pijnenburg Y, Wolters E, Rademakers R, Geschwind DH, Kramer JH, Rosen HJ, Rankin KP, Grinberg LT, Seeley WW, Sturm V, Perry DC, Miller BL, Rabinovici GD, Gorno-Tempini ML

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.

2025

Holmes BB, Weigel TK, Chung JM, Kaufman SK, Apresa BI, Byrnes JR, Kumru KS, Vaquer-Alicea J, Gupta A, Rose IVL, Zhang Y, Nana AL, Alter D, Grinberg LT, Spina S, Leung KK, Miller BL, Condello C, Kampmann M, Seeley WW, Coutinho-Budd JC, Wells JA

Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease.

2025

de Bruin H, Groot C, Barthel H, Bischof GN, Blazhenets G, Boellaard R, Boon BDC, Brendel M, Cash DM, Coath W, Day GS, Dickerson BC, Doering E, Drzezga A, van Dyck CH, van Eimeren T, van der Flier WM, Fredericks CA, Fryer TD, van de Giessen E, Gordon BA, Graff-Radford J, Grinberg LT, Hansson O, Hobbs DA, Hoenig MC, Höglinger G, Irwin DJ, Jones PS, Josephs KA, Katsumi Y, La Joie R, Lee EB, Levin J, Malpetti M, McGinnis SM, Mecca AP, Mohanty R, Nasrallah IM, O'Brien JT, O'Dell RS, Palleis C, Perneczky R, Phillips JS, Putcha D, Rabinovici GD, Rahmouni N, Rosa-Neto P, Rowe JB, Rullmann M, Sabri O, Saur D, Schildan A, Schott JM, Schroeter ML, Seeley WW, Servaes S, Sintini I, Smith R, Spina S, Stevenson J, Stomrud E, Strandberg O, Therriault J, Tideman P, Touroutoglou A, Trainer AE, Visser D, Wekselman F, Weston PSJ, Whitwell JL, Wolk DA, Yong K, Pijnenburg YAL, Franzmeier N, Ossenkoppele R

Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U.

2025

Alidadiani S, Faura J, Wynants S, Peeters N, Van den Broeck M, De Witte L, Policarpo R, Cheung S, Pottier C, Ghayal NB, Mol MO, van Blitterswijk M, Udine E, DeJesus-Hernandez M, Baker M, Finch NA, Asmann YW, van Rooij JGJ, Nguyen AT, Ross Reichard R, Nana AL, Lopez OL, Boxer AL, Rosen HJ, Spina S, Herms J, Josephs KA, Petersen RC, Rissman RA, Hiniker A, Ang LC, Grinberg LT, Halliday GM, Boeve BF, Graff-Radford NR, Seelaar H, Neumann M, Kofler J, White CL, Seeley WW, van Swieten JC, Dickson DW, Mackenzie IRA, De Coster W, Rademakers R

Tauopathy strains differentially replicate in vitro in the presence of mutant tau monomer.

2025

Brown CK, Frost MP, Holec SAM, Seeley WW, Grinberg LT, Olson SH, Woerman AL

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation.

2025

Zhu B, Wangzhou A, Yu D, Li T, Schmidt R, De Florencio SL, Chao L, Thurber AL, Zhou M, Msheik Z, Perez Y, Grinberg LT, Spina S, Ransohoff RM, Kriegstein AR, Seeley WW, Nowakowski T, Piao X

Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration.

2025

Murray ME, Smith C, Menon V, Keene CD, Lein E, Hawrylycz M, Aguzzi A, Benedetti B, Brose K, Caetano-Anolles K, Sillero MIC, Crary JF, De Jager PL, Faustin A, Flanagan ME, Gokce O, Grant SGN, Grinberg LT, Gutman DA, Hillman EMC, Huang Z, Irwin DJ, Jones DT, Kapasi A, Karch CM, Kukull WT, Lashley T, Lee EB, Lehner T, Parkkinen L, Pedersen M, Pritchett D, Rutledge MH, Schneider JA, Seeley WW, Shepherd CE, Spires-Jones TL, Steen JA, Sutherland M, Vickovic S, Zhang B, Stewart DJ, Keiser MJ, Vogel JW, Dugger BN, Phatnani H

Associations of neurodegenerative and cerebrovascular neuropathology with frailty in a diverse sample.

2025

Bozi-Soares F, Aliberti MJR, Justo AFO, Leite REP, Grinberg LT, Paes VR, Rodriguez RD, Pasqualucci CA, Ferrioli E, Suemoto CK

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