Sleep dysfunction in tauopathies

Sleep dysfunction in tauopathies
Sleep dysfunction is a common clinical feature of underlying Alzheimer's disease and FLTD-tau pathologies. The Grinberg lab is characterizing the deposition of tau pathology in areas involved in sleep regulation in patients with tauopathies.


Tauopathies are a group of neurodegenerative diseases that feature deposition of abnormal phospho-tau protein in the brain. The most common tauopathies are Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration and Pick’s disease. Tauopathies are progressive and there is no treatment available to date. Among the plethora of disruptive clinical symptoms, most patients suffer from sleep dysfunction which directly impacts the patient and caregiver quality of life. To understand the biological basis of the sleep disturbances in each tauopathy may help to provide personalized symptomatic treatment and improve the patient quality of life. In collaboration with Christine Walsh, PhD and Thomas Neylan, MD, we are characterizing deposition of abnormal tau protein in areas involved in sleep regulation in patients with tauopathies.

Funding Sources

The Tau Consortium

Related publications

Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease.

Journal of Alzheimer's disease
Ehrenberg AJ, Suemoto CK, de Paula França Resende E, Petersen C, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, You M, Oh J, Nitrini R, Pasqualucci CA, Jacob-Filho W, Kramer JH, Gatchel JR, Grinberg LT

Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study.

Journal of neuropathology and experimental neurology
Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT