Sleep disruption in PSP

Tauopathies are a group of neurodegenerative diseases that feature deposition of abnormal phospho-tau protein in the brain. The most common tauopathies are progressive supranuclear palsy, corticobasal degeneration and Pick’s disease. Tauopathies are progressive and there is no treatment available to date. Among the plethora of disruptive clinical symptoms, most patients suffer from sleep dysfunction which directly impacts the patient and caregiver quality of life. To understand the biological basis of the sleep disturbances in each tauopathy may help to provide personalized symptomatic treatment and improve the patient quality of life. In collaboration with Christine Walsh we are characterizing deposition of abnormal phospho—tau protein in areas involved in sleep regulation in patients with tauopathies.

This study is sponsored by the Tau consortium.